See the impact of NASCOBAL® Nasal Spray on healthy vitamin B12 levels
Clinically proven to have increased vitamin B12 levels from the first dose1*
- Achieved mean peak serum vitamin B12 concentration within 1.5 hours1*
- Reached mean peak concentration of 1021 pg/mL1*
- At 72 hours, mean serum vitamin B12 level was increased by 46% above baseline1*
In 21 healthy volunteers under fasting conditions, a single 500 mcg dose of NASCOBAL® was given and monitored for 3 days. Data are based on baseline uncorrected serum vitamin B12 levels.
Intranasal administration has maintained healthy vitamin B12 levels2
- Once-a-week intranasal dosing maintained higher serum vitamin B12 levels than 1 intramuscular vitamin B12 injection after 28 days2
In 24 patients with a history of pernicious anemia, a single-dose cyanocobalamin 100 mcg/mL intramuscular (IM) injection was given and monitored for 28 days, followed by 4 once-weekly doses of intranasal (IN) vitamin B12 gel 500 mcg/0.1 mL. Mean baseline serum vitamin B12 prior to IN dosing = 351.4 pg/mL, and at day 28 = 480.7 pg/mL.2
In a separate study, bioavailability of vitamin B12 nasal spray was 10% less than vitamin B12 nasal gel. Clinical significance is unknown.3