NASCOBAL® NASAL SPRAY:
A UNIQUE WAY TO DELIVER VITAMIN B12

  • Unique intranasal delivery system
    Designed to absorb serum vitamin B12 directly into the bloodstream
  • The only FDA-approved vitamin B12 nasal spray
    Clinically proven to have increased and maintained healthy vitamin B12 levels1
  • Convenient, once-weekly dosing regimen
    Self-administered fine mist: 1 spray, 1 nostril, 1x a week
    NASCOBAL® Nasal Spray should be administered at least one hour before
      and one hour after ingestion of hot foods or liquids
  • Achieved mean peak serum vitamin B12 concentration within 1.5 hours2*
  • Reached mean peak concentration of 1021 pg/mL2*
  • At 72 hours, mean serum vitamin B12 level was increased by 46% above baseline2*

*In 21 healthy volunteers under fasting conditions, a single 500-mcg dose of NASCOBAL® was given and monitored for 3 days. Data are based on baseline-uncorrected serum vitamin B12 levels.2

HOW TO USE NASCOBAL®

Hold:

  • The unit contains only 1 spray: DO NOT prime before use
  • Blow nose gently to clear both nostrils
  • Hold the unit with your thumb, supporting it at the
    bottom, and your index and middle fingers on either side
    of the nozzle

Administer:

  • Gently close 1 nostril with your other index finger. Insert the nozzle into open nostril approximately ½ inch, or as far as feels comfortable, and tilt your head slightly forward. Do not press the plunger yet
  • Breathe in gently through your nose, close your mouth, and at the same time, press the plunger firmly
    with your thumb

Note:

Do not drink hot liquids or eat hot foods at
least 1 hour before and 1 hour after taking
NASCOBAL® Nasal Spray.

Remove:

  • Remove the nozzle from your nostril. At the same time, keep your head level for 10 to 20 seconds while gently breathing in through your nose and breathing out through your mouth

Reference: 1. Data on File. DOF-NS-01. Endo Pharmaceuticals Inc.; 2015.

Reference: 2. Data on File. DOF-NS-02. Endo Pharmaceuticals Inc.; 2015.